Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver.
Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin.
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.
Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component.
hTid-1, a human DnaJ protein, modulates the interferon signaling pathway.
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.
PTP1B regulates leptin signal transduction in vivo.
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.
Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.
SOCS2 negatively regulates growth hormone action in vitro and in vivo.
Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling.
Janus kinases affect thrombopoietin receptor cell surface localization and stability.
The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor.
The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons.
Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.
Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.
Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.
Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells.
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.
Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity.
Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.
Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
Heme controls the regulation of protein tyrosine kinases Jak2 and Src.
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.
The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides.
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
JAK2V617F activates Lu/BCAM-mediated red cell adhesion in polycythemia vera through an EpoR-independent Rap1/Akt pathway.
Mpl traffics to the cell surface through conventional and unconventional routes.
RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.
CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.
Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice.
JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice.
Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling.
ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells.
Physical proximity and functional cooperation of glycoprotein 130 and glycoprotein VI in platelet membrane lipid rafts.
Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function.
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
The interleukin-5/receptor interaction activates Lyn and Jak2 tyrosine kinases and propagates signals via the Ras-Raf-1-MAP kinase and the Jak-STAT pathways in eosinophils.
Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha.
JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.
IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.
Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component.
Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.
Signaling of type II oncostatin M receptor.
JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation.
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.
Cloning and characterization of human Jak-2 kinase: high mRNA expression in immune cells and muscle tissue.
Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors.
The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor.
Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
Assembly of hexameric IL-6 receptor
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
IL6ST is tyrosine phosphorylated
Tyrosine phosphorylated IL6ST binds STAT1,STAT3
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
Phosphorylated STATs are released
PTPN11 binds p-Y759-IL6ST
Serine phosphorylation of STATs
PTP1B binds the GH receptor complex
p-STAT5A/B dissociates from the Growth Hormone receptor
PTP1B dephosphorylates GHR
Prolactin receptor is internalized
PRLR binds SCF beta-TrCP complex
PRLR is phosphorylated at Ser-349
Disassociation and translocation of STATs to the nucleus
PRMT5 is tyrosine phosphorylated by JAK2 V617F
Adherens junctions interactions
Interleukin-23 binds interleukin-23 receptor
Interleukin-12 binds Interleukin-12 receptor
IL12RB1:TYK2 binds IL12RB2:JAK2
Interleukin-27 binds Interleukin-27 receptor
IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
Phosphorylated SHC1 recruits GRB2:GAB2
Phosphorylated SHC recruits GRB2:SOS1
Gab2 binds the p85 subunit of Class 1A PI3 kinases
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAS GEFs promote RAS nucleotide exchange
OSM,LIF,CTF1 receptor complex binds gp130
OSM binds LIFR:JAKs,OSMR:JAKs
LIFR:JAKs bind gp130:JAKs:CNTFR
Interleukin-4 and Interleukin-13 signaling
IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
JAK1 binds IL4R in IL4-bound IL4R1
IL4:IL4R:JAK2 binds IL13RA1:TYK2
p-Y705-STAT3,p-Y641-STAT6 dissociate
IL4:IL4R:JAK2 binds IL2RG:JAK3
JAK1 phosphorylates STAT3,STAT6
IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
JAK1 binds IL4R in IL13-bound IL13R type II
IL13:IL13RA:TYK2 binds IL4R:JAK2
STAT3,STAT6 bind p-Y-IL4R
STAT1,STAT3,STAT6 bind IL13:IL13R type II
STAT1,STAT3,STAT6 phosphorylation
IL35 binds IL-12RB2:IL6ST receptor
Transphosphorylation of JAK1
Binding of STAT1 to p-IFNGR1
Phosphorylation of STAT1 by JAK kinases
Phosphorylation of IFNGR1 by JAK kinases
Release of STAT1 dimer from active receptor unit
SOCS-1 and SOCS-3 binds to p-JAK2
Interferon gamma signaling
Tyrosine kinases phosphorylate the receptor
Activation of STAT5a/b by JAK2
JAK2 is phosphorylated, activated
SHC1 bound to the common beta chain becomes tyrosine phosphorylated
STAT5 is recruited by JAK2
Recruitment of SHC1 is mediated by Y593 of the common beta chain
The receptor is activated
Interleukin-12 dissociates from Interleukin-12 receptor
Interleukin-27 dissociates from Interleukin-27 receptor
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
STAT4 binds p-Y-IL23R in IL23:IL23 receptor
p-Y693-STAT4 dissociates after IL12:IL12R interaction
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
IL12 bound to IL12R internalises
IL35 binds IL6ST:IL6ST receptor
IL35 binds IL12RB2:IL12RB2 receptor
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
STAT1 associates with IL6ST:IL6ST
p-STAT1 dissociates from IL6ST:IL6ST
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
STAT4 binds IL12RB2:IL12RB2
p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
IL35 binds IL27RA:IL12RB2 receptor
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
Interleukin-35 Signalling
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
EPOR-associated PI3K phosphorylates PIP2 to PIP3
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
Phosphorylation of STAT1 at Ser727
SHP1 and SHP2 bind the common beta chain
SHC1 mediates cytokine-induced phosphorylation of GAB2
p-S585-IL3RB binds 14-3-3 proteins
Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
GM-CSF receptor alpha:GM-CSF binds Bc
Phosphorylated SHC1 recruits SHIP
The SHC1:SHIP1 complex is stabilized by GRB2
IL3RB is phosphorylated on Ser-585
SHP1 and SHP2 dephosphorylate Y628 of IL3RB
14-3-3 zeta binding allows recruitment of PI3K
p-STAT5 dissociates from the receptor complex
Phosphorylation of STATs downstream of KIT mutants
JAK2 binds to p-KIT mutants
Recruitment of STATs by KIT mutants
Dimerization of STATs downstream of KIT mutants
Phosphorylation of JAK2 downstream of KIT mutants
Disassociation and translocation of STATs to the nucleus downstream of KIT mutants
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
Activated JAK1 binds RAF1
JAK1-mediated phosphorylation of RAF1
JAK1-activated RAF1 phosphorylates MAPKs
Prolactin receptor ligands bind the prolactin receptor
GH:GHR:JAK2 complex undergoes a conformational change
Growth hormone receptor dimerizes
Growth hormone binds the growth hormone receptor
Growth hormone receptor binds JAK2
JAK2 phosphorylation of GHR
Tyrosine phosphorylation of STAT3 by IL6 receptor
p-Y705-STAT3 dissociates from IL6 receptor
Tyrosine phosphorylated IL6ST binds STAT3
UniProt record O60674 (JAK2)