Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Assignment of the human pro-melanin-concentrating hormone gene (PMCH) to chromosome 12q23-q24 and two variant genes (PMCH1 and PMCHL2) to chromosome 5p14 and 5q12-q13.
Antisense expression of the human pro-melanin-concentrating hormone genes.
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Brain variant-locus transcripts derive from PMCHL1, not PMCHL2.
"to be derived from the 5p (pMCHL1), not the 5q (pMCHL2) locus"
Structure and expression of the variant melanin-concentrating hormone genes: only PMCHL1 is transcribed in the developing human brain and encodes a putative protein.
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PMCHL2 is not transcribed in human brain.
"we provided strong evidence for the expression of the PMCHL1 gene but not the PMCHL2 gene in the human fetal, newborn, and adult brains"
Birth of two chimeric genes in the Hominidae lineage.
Primate-specific spliced PMCHL RNAs are non-protein coding in human and macaque tissues.
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PMCHL2 transcripts are restricted to testis.
"Thus, PMCHL1 transcripts are found in testis and fetal brain and are more abundant than PMCHL2 transcripts that are observed only in testis."
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No PMCHL protein is detected in expressing tissues.
"This strongly suggests that these putative proteins are not translated in vivo in the human and macaque tissues that we tested."
Pairwise comparison of PMCHL2 (Q9BQD1) with parent pro-MCH (PMCH, P20382)