Falcon deep research report for BIN1
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Falcon corroborates the review's framing of BIN1 as a modular BAR/SH3 membrane-remodeling and scaffolding adaptor that couples membrane-curvature generation to recruitment of diverse partners across tissue-specific contexts.
"BIN1 functions as a versatile membrane-remodeling and scaffolding protein whose modular domain architecture enables integration of membrane curvature generation with recruitment of diverse protein partners to execute tissue-specific cellular programs."
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin1, a novel Myc interacting protein.
Bin2, a functionally nonredundant member of the BAR adaptor gene family.
Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein.
Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.
A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants.
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays.
The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.
Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy.
The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins.
Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers.
Hepatitis C virus infection protein network.
The membrane-tubulating potential of amphiphysin 2/BIN1 is dependent on the microtubule-binding cytoplasmic linker protein 170 (CLIP-170).
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.
The myotubularin-amphiphysin 2 complex in membrane tubulation and centronuclear myopathies.
Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches.
Mutations in BIN1 associated with centronuclear myopathy disrupt membrane remodeling by affecting protein density and oligomerization.
Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease.
Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton.
BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.
Roles of tau protein in health and disease.
Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain.
HENA, heterogeneous network-based data set for Alzheimer's disease.
Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Multimodal cell maps as a foundation for structural and functional genomics.
BIN1 is a novel MYC-interacting protein with features of a tumour suppressor.
Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle.
F- and N- BAR domain proteins bind the clathrin-coated pit
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2