Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Defining the membrane proteome of NK cells.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells.
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Primary characterization paper demonstrating RASAL3 is a hematopoietic RasGAP.
"In this study, we identified a novel Ras GTPase-activating proteins protein, RASAL3, which is predominantly expressed in cells of hematopoietic lineages, including NKT, B, and T cells."
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RASAL3 knockout mice show decreased NKT cell numbers and function.
"We established systemic RASAL3-deficient mice, and the mice exhibited a severe decrease in NKT cells in the liver at 8 weeks of age."
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RASAL3-deficient NKT cells display enhanced ERK phosphorylation, indicating loss of Ras-ERK regulation.
"RASAL3-deficient NKT cells treated with alpha-GalCer in vitro presented augmented Erk phosphorylation, suggesting that there is dysregulated Ras signaling in the NKT cells of RASAL3-deficient mice."
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RASAL3 is predominantly expressed in hematopoietic lineages.
"RASAL3, which is predominantly expressed in cells of hematopoietic lineages, including NKT, B, and T cells."
A reference map of the human binary protein interactome.
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High-throughput interactome mapping identified multiple RASAL3 interaction partners.
"The dataset, versioned HI-III-20 (Human Interactome obtained from screening Space III, published in 2020), contains 52,569 verified PPIs involving 8,275 proteins"
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RASAL3 shows self-interaction suggesting homodimerization.
"proteins originate from a common ancestor that could self-interact"
RAS GAPs stimulate RAS GTPase activity
Deep research synthesis on RASAL3 function
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Synthesizes evidence from multiple studies including Muro 2015, Shin 2018, Saito 2021, Olivier 2024.
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Documents RASAL3 GAP activity toward Ras and Rac2 substrates.
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Details roles in T cell survival, NKT cell regulation, neutrophil restraint, and DC migration.
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Describes CCDC88B-RASAL3-ARHGEF2 complex in dendritic cells.
Cyberian deep research on RASAL3 function