Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
The MerR-like transcriptional regulator BrlR contributes to Pseudomonas aeruginosa biofilm tolerance.
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BrlR is a biofilm-expressed MerR-family regulator required for high-level biofilm drug tolerance.
"Here we report that the transcriptional regulator BrlR, a member of the MerR family of multidrug transport activators, plays a role in the high-level drug tolerance of biofilms formed by Pseudomonas aeruginosa."
The MerR-like regulator BrlR impairs Pseudomonas aeruginosa biofilm tolerance to colistin by repressing PhoPQ.
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BrlR binds the oprH-phoPQ promoter (EMSA) and represses the operon.
"Taken together with the gene expression results, our findings indicate that BrlR is involved in transcriptional regulation of the oprH-phoPQ operon, acting as a repressor."
BrlR from Pseudomonas aeruginosa is a c-di-GMP-responsive transcription factor.
UniProt entry Q9HUT5 (BRLR_PSEAE)