Annotation inferences using phylogenetic trees

Phylogenetic (IBA) annotations from GO_Central placing F6LAX4 in the PP2A regulatory subunit A family (PANTHER PTHR10648); the protein phosphatase type 2A complex (GO:0000159) and protein phosphatase regulator activity (GO:0019888) annotations are propagated from experimentally characterized orthologs across yeast, fly, worm, mouse and Dictyostelium (WITH/FROM column of the GOA).

Electronic Gene Ontology annotations created by ARBA machine learning models

ARBA rule-based (IEA) annotations assigning nucleus (GO:0005634), cytoplasm (GO:0005737) and protein-containing complex (GO:0032991). The localization terms are family-consistent; the generic protein-containing complex term is subsumed by the more specific GO:0000159.

file:WHEAT/F6LAX4/F6LAX4-deep-research-falcon.md

Deep-research report (falcon / Edison Scientific Literature) - functional annotation of wheat PP2A scaffolding A subunit (F6LAX4 / LOC123103357).

F6LAX4 is a PP2A structural/scaffold A subunit (PR65/PP2AA family) with HEAT/ARM-like repeats; no primary literature explicitly characterizes this exact wheat gene, so functional annotation is high-confidence family-level inference grounded in canonical PP2A-A structure-function evidence.
The PP2A A subunit is an alpha-solenoid of ~15 HEAT repeats (~65 kDa) forming a horseshoe-shaped scaffold; it has no catalytic activity but binds the catalytic C subunit to form the A-C core enzyme and recruits regulatory B subunits, thereby controlling substrate specificity, localization, and activity of PP2A holoenzymes.
Plant PP2A A subunits (e.g. Arabidopsis RCN1/PP2AA1) function in auxin distribution and root development, brassinosteroid signaling (dephosphorylation of BRI1 and the BZR1 transcription factor), and stress responses; A and B subunits show diverse subcellular localizations whereas catalytic C subunits are predominantly cytosolic.