Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation by the MGI curatorial staff, curated orthology

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic Gene Ontology annotation based on Rhea mapping

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

Combined Automated Annotation using Multiple IEA Methods

Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia.

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments.

Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice.

Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization.

Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice.

Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice.

Cell type-autonomous and non-autonomous requirements for Dmrt1 in postnatal testis differentiation.

The ectonucleotidases alkaline phosphatase and nucleoside triphosphate diphosphohydrolase 2 are associated with subsets of progenitor cell populations in the mouse embryonic, postnatal and adult neurogenic zones.

Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles.

Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification.

Two alkaline phosphatase genes are expressed during early development in the mouse embryo.

Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle.

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.

A protective role for FGF-23 in local defence against disrupted arterial wall integrity?

Effects of pH on the production of phosphate and pyrophosphate by matrix vesicles' biomimetics.

The Functional co-operativity of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 during initiation of Skeletal Mineralization.

Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.

Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.

TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream.

Stage-specific expression of alkaline phosphatase during neural development in the mouse.

Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6.

Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.

Deep research report: mouse Alpl / tissue-nonspecific alkaline phosphatase (TNAP)