Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells.

The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.

Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells.

The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone.

STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas.

IL-4 induces a wide-spectrum intracellular signaling cascade in CD8+ T cells.

PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.

microRNA-222 controls neovascularization by regulating signal transducer and activator of transcription 5A expression.

CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation.

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.

STAT5 in human basophils: IL-3 is required for its FcεRI-mediated phosphorylation.

STAT heterodimers in immunity: A mixed message or a unique signal?

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

A proteome-scale map of the human interactome network.

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells.

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

Identification and purification of human Stat proteins activated in response to interleukin-2.

Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.

Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain.

Prolactin receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways.

p-STAT5A/B dissociates from the Growth Hormone receptor

ERBB4s80:STAT5A complex translocates to the nucleus

ERBB4s80 binds STAT5A

IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5

Recruitment of STATs

Phosphorylation of STATs

Dimerization of STATs

Disassociation and translocation of STATs to the nucleus

Phosphorylation of STAT5 by cytosolic FGFR1 fusions

STAT binds to the active receptor

Recruited STAT5 is phosphorylated

Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment

p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B

Activation of STAT5a/b by JAK2

STAT5 is recruited by JAK2

ERBB4s80:STAT5A binds CSN2 gene promoter

p-Y-STAT3:p-STAT5 translocates to the nucleus

IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B

IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5

p-STAT5 binds CISH, SOCS1 and SOCS2 gene

IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5

Phosphorylated STAT5 is released

p-STAT5 dissociates from the receptor complex

Phosphorylation of STATs downstream of KIT mutants

Recruitment of STATs by KIT mutants

Dimerization of STATs downstream of KIT mutants

Disassociation and translocation of STATs to the nucleus downstream of KIT mutants

FLT3 ITD mutants phosphorylate STAT5

PTPN11:p-STAT5 dissociates from mutant FLT3

PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3

PTPN11:p-STAT5 binds BCL2L1 promoter

p-STAT5 dissociates from mutant FLT3

p-STAT5 translocates to nucleus downstream of mutant FLT3

p-STAT5 binds the CDKN1A gene

p-STAT5 binds the NOX4 promoter

ALK-, STAT3- and MECP2-dependent STAT5A gene repression

p-STAT5 dissociates from FLT3 fusion proteinsp-

FLT3 fusions activate STAT5

Phosphorylated STAT5 dimer binds the IL4R gene

Deep research (falcon): functional annotation report for human STAT5A (P42229)