Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription.
DCDC2 is associated with reading disability and modulates neuronal development in the brain.
Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.
A proteome-scale map of the human interactome network.
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The study contributes a systematic binary human interaction map; the two source-specific DCDC2 pairs are supported by its curator-deposited interaction records.
"Combining high-quality binary pairs from the literature with systematic
binary maps"
DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.
A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation.
DCDC2 Mutations Cause Neonatal Sclerosing Cholangitis.
A reference map of the human binary protein interactome.
Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin.
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Mouse Dcdc2 deletion alone leaves the tested neocortical migration assays grossly normal, while Dcx RNAi causes greater defects in the mutant background.
"Dcx RNAi impairs neuronal migration more in Dcdc2 knockouts than in wt animals."
Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene homolog Dcdc2 in the rat.
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Rat embryonic Dcdc2 knockdown produces migration abnormalities; DCDC2 overexpression rescues periventricular heterotopia but not all migration phenotypes.
"rescued the periventricular
heterotopia phenotype"
Functional analyses of lissencephaly-related proteins in Dictyostelium.
Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.
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Worm RPI-1 localizes to ciliary and cytoplasmic microtubules and supplies experimental localization evidence for the shared PAINT ancestor.
"RPI-1::GFP appears to localise to ciliary and cytoplasmic microtubules"
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.