Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver.
Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.
Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells.
The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities.
The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons.
Generation of Janus kinase 1 (JAK1) conditional knockout mice.
IL-7-induced phosphorylation of the adaptor Crk-like and other targets.
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells.
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.
Il7:p-Y449-Il7r:Jak1:Il2rg:Jak3 binds Pi3k regulatory subunits
IL7r is phosphorylated on Y449
Il15ra:Il15:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3 phosphorylates Shc1
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3 binds Shc1
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1 binds Grb2
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2:Gab2 phosphorylates Gab2
Il2rb and Il2rg are phosphorylated
Csf3:Csf3r induces phosphorylation of Jak1
p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5
p-Y-Jak1 phosphorylates Csf3r in Csf3 dimer:2xCsf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2
Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2
Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7
Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed
Jaks associate with IL6RB (gp130)
Falcon deep research summary for mouse Jak1
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Jak1 is a cytosolic receptor-associated non-receptor tyrosine kinase.
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Falcon synthesis supports Jak1 as a core mediator of cytokine receptor JAK-STAT signaling through receptor and STAT phosphorylation.
AIGR curator notes for Jak1