Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
IFT-81 and IFT-74 are required for intraflagellar transport in C. elegans.
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IFT-81 is expressed in sensory neurons, localizes at the ciliary base, interacts with IFT-74, and is required for IFT in mature cilia.
"ift-81 and ift-74 mutants similarly exhibited weak anomalies in cilia formation and obvious disruptions of transport in mature cilia"
Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia.
DYF-5/MAK-dependent phosphorylation promotes ciliary tubulin unloading.
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The IFT-74/81 module binds tubulin; DYF-5 phosphorylation of IFT-74 lowers its tubulin affinity about sixfold.
"the ciliary kinase DYF-5/MAK phosphorylates multiple sites within the tubulin-binding module of IFT-74, reducing the tubulin-binding affinity of IFT-74/81 approximately sixfold"
Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.
UniProt entry for ift-81 (worm)
WormBase gene description for ift-81 (worm)