Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
Liver-specific activities of FGF19 require Klotho beta.
betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c.
C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors.
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.
Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain.
PI3K-containing complexes phosphorylate PIP2 to PIP3
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4
Autocatalytic phosphorylation of FGFR4
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
Activated FGFR4 phosphorylates PLCG1
Activated FGFR4 binds PLCG1
p-4Y-PLCG1 dissociates from activated FGFR4
Activated FGFR4 phosphorylates FRS2
Activated FGFR4 binds FRS2
Activated FGFR4:p-SHC1 binds GRB2:SOS1
Activated FGFR4 binds SHC1
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 phosphorylates SHC1
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
Activated FGFR4 binds FRS3
Activated FGFR4 phosphorylates FRS3
Activated FGFR4 phosphorylates PPTN11
Activated FGFR4:p-FRS bind to PPTN11
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4:p-FRS binds GRB2:SOS1
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
CBL ubiquitinates FRS2 and FGFR4
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4-associated PI3K phosphorylates PIP2 to PIP3
p-CBL:GRB2 binds p-FRS2:activated FGFR4
RAS GEFs promote RAS nucleotide exchange
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
FGF19 deep research (Falcon/Edison)