GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:11146555
Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16.
PMID:12894224
Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence.
PMID:14654789
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.
PMID:16494870
Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein.
PMID:19158679
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.
PMID:19946888
Defining the membrane proteome of NK cells.
PMID:20890285
IFI16 is an innate immune sensor for intracellular DNA.
PMID:21478870
A diverse range of gene products are effectors of the type I interferon antiviral response.
PMID:21573174
IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway.
PMID:21575908
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
PMID:22046441
IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes.
PMID:22291595
The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication.
PMID:22658674
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
PMID:24413532
Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1.
PMID:24531343
The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.
PMID:30833792
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
PMID:7536752
IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines.
PMID:9642285
The human interferon-inducible protein, IFI 16, is a repressor of transcription.
PMID:9766636
The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.
Reactome:R-HSA-1834951
IFI16 binds cytosolic dsDNA