Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Intramembrane proteolytic cleavage of a membrane-tethered transcription factor by a metalloprotease depends on ATP.
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SpoIVFB cleaves pro-sigK to release active sigK
"The Bacillus subtilis SpoIVFB protein is a putative metalloprotease that cleaves membrane-tethered Pro-sigma(K), releasing sigma(K) to direct transcription of genes necessary for spore formation."
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SpoIVFB CBS domain interacts with pro-sigK and ATP modulates this interaction
"The CBS domain of SpoIVFB was shown to interact with Pro-sigma(K) and ATP changed the interaction"
UniProt entry for RNA polymerase sigma-K factor (sigK/spoIVCB/spoIIIC)
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SigK is synthesized as a precursor with a propeptide that is removed
"PROPEP 1..20 /id="PRO_0000032588""
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SigK contains a helix-turn-helix DNA-binding motif at residues 251-270
"DNA_BIND 251..270 /note="H-T-H motif""
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SigK belongs to the sigma-70 factor family
"Belongs to the sigma-70 factor family."
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Sigma factors are initiation factors that promote RNAP attachment to specific sites
"Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released."
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The sigK gene is produced by chromosomal rearrangement - excision of skin element
"The spoIVCB gene is an incomplete structural gene that is capable of encoding only the N-terminal half of sigma-K."
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SigK interacts with SpoIVFB
"P12254; P26937: spoIVFB; NbExp=2; IntAct=EBI-15806052, EBI-15806037"
Deep research report on sigK function and regulation
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SigK operates in a hierarchical feed-forward mother-cell program
"sigK operates in a hierarchical, feed-forward mother-cell program following sigE and preceding GerE, activating coat/cortex/germination genes"