Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000041

Gene Ontology annotation based on UniPathway vocabulary mapping

GO_REF:0000116

Automatic Gene Ontology annotation based on Rhea mapping

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:12864730

Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system.

DDC associates with androgen receptor and enhances ligand-dependent reporter activity in prostate-cell experiments; this supports contextual nuclear receptor binding.

PMID:16338639

The assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PD.

The paper describes expressed human AADC activity assays in dopamine-synthesis experiments.

PMID:19056867

Large-scale proteomics and phosphoproteomics of urinary exosomes.

DDC was detected in the urinary extracellular-vesicle proteomics dataset, supporting contextual localization.

PMID:19703902

Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1.

Human DDC converts L-DOPA to dopamine and interacts with DJ-1 and TH; DJ-1 modulates DDC activity.

PMID:7567987

Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen.

The paper states the DOPA and 5-hydroxytryptophan decarboxylation reactions while identifying rat insulinoma AADC as an autoantigen.

Reactome:R-HSA-209859

Decarboxylation of 5-hydroxytryptophan forms serotonin

AADC, functioning as a PLP-dependent homodimer, decarboxylates 5-hydroxytryptophan to serotonin in the cytosol.

Reactome:R-HSA-209924

Dopa is decarboxylated to dopamine

AADC (DOPA decarboxylase) decarboxylates dopa to form dopamine in the cytosol.

PMID:22143761

Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.

Human DDC apoenzyme structures and PLP-addition kinetics explain cofactor-dependent organization of the catalytic sites.

PMID:15532536

Identification and characterization of a novel form of the human L-dopa decarboxylase mRNA.

An alternative coding transcript was isolated from human placenta and detected at high levels in human kidney.

PMID:8670114

Cloning and expression of pig kidney dopa decarboxylase: comparison of the naturally occurring and recombinant enzymes.

Pig-kidney and recombinant DDC differ in cofactor occupancy and maximal activity, while supporting the conserved decarboxylase enzyme class.

file:human/DDC/DDC-uniprot.txt

UniProtKB P20711 DDC record

file:human/DDC/DDC-source-evidence.yaml

DDC authored source-evidence guide

file:human/DDC/DDC-primary-source-notes.md

DDC primary-source assay and table locators