Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic Gene Ontology annotation based on Rhea mapping
Starvation promotes Dictyostelium development by relieving PufA inhibition of PKA translation through the YakA kinase pathway.
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YakA governs the growth-to-development transition by regulating the cell cycle, repressing growth-phase genes and inducing developmental genes.
"The YakA protein kinase governs this transition by regulating the cell cycle, repressing growth-phase genes and inducing developmental genes"
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YakA initiates development by inhibiting PufA, which represses translation of pkaC (PKA-C) mRNA.
"YakA regulates the initiation of development by inhibiting the expression of PufA"
The protein kinase YakA regulates g-protein-linked signaling responses during growth and development of Dictyostelium.
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yakA-null cells resemble G-protein beta-subunit nulls, fail to enter development, and have defects in folic acid-induced (G-protein-mediated) responses.
"The yakA-null cells have strong defects in folic acid-induced responses, such as actin polymerization and cGMP accumulation, indicating that they play a role in G-protein-mediated signaling responses"
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YakA-GFP localizes to the cytosol and YakA is proposed to be a functional homolog of mammalian Dyrk2/Dyrk3 dual-specificity kinases.
"We localized YakA-GFP to the cytosol suggesting that YakA may be a functional homolog of its mammalian counterparts Dyrk2 and Dyrk3"
Role for YakA, cAMP, and protein kinase A in regulation of stress responses of Dictyostelium discoideum cells.
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yakA-null cells are hypersensitive to nitrosative/oxidative stress, and a second-site pkaC mutation suppresses this sensitivity.
"yakA null cells are hypersensitive to nitrosoative/oxidative stress and that a second-site mutation in pkaC suppresses this sensitivity"
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YakA is necessary for the starvation-induced decrease in vegetative gene expression, including the decrease in pufA mRNA.
"YakA is necessary for the decrease in vegetative gene expression that occurs when cells are starved and in particular, for the decrease in the mRNA levels for the pufA gene"
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YakA is a general sensor of environmental conditions that effects changes through PKA.
"Our findings indicate that YakA is a general sensor of environmental conditions effecting changes through PKA"
Chemoattractant signaling in dictyostelium discoideum.
High-throughput analysis of spatio-temporal dynamics in Dictyostelium.
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yakA-disrupted cells cluster with 'developmentally null' mutants, failing to complete multicellular development.
"This cluster includes a group of 'developmentally null' mutants in which genes such as mkpA, piaA, yakA and dagA are disrupted"
KeaA, a Dictyostelium Kelch-domain protein that regulates the response to stress and development.
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YakA is an effector of starvation gene-expression changes, up- regulating pkaC, the adenylyl cyclase acaA and the cAMP receptor carA.
"YakA is an effector of the gene expression changes that follow starvation including the down-regulation of vegetative genes, the up-regulation of the cAMP-dependent protein kinase, pkaC, the adenylyl cyclase acaA, and the cAMP receptor carA"
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YakA regulates the cell cycle during growth and survival to oxidative, nitrosative and thermal stresses.
"During growth YakA regulates the cell cycle, and the survival to oxidative, nitrosoative and thermal stresses"
Bio-electrospraying and aerodynamically assisted bio-jetting the model eukaryotic Dictyostelium discoideum: assessing stress and developmental competency post treatment.
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yakA transcript is significantly induced under hyperosmotic (sorbitol) shock.
"Our data confirm gapA, rtoA and yakA are commonly induced under hyperosmotic shock"
Glutathione initiates the development of Dictyostelium discoideum through the regulation of YakA.
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yakA initiates development and induces the expression of PKA-C, ACA and cAR1, and its expression is regulated by intracellular glutathione.
"the expression of yakA, which initiates development and induces the expression of PKA-C, ACA, and cAR1, was regulated by the intracellular concentration of GSH"
Response of Dictyostelium discoideum to UV-C and involvement of poly (ADP-ribose) polymerase.
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UV-C affects expression of developmentally important genes including yakA that regulate cell-cycle exit and the growth-to-differentiation transition.
"failed to affect expression of car1, aca, yakA, crucial for regulating cell cycle exit and growth to differentiation transition"
Curcumin inhibits development and cell adhesion in Dictyostelium discoideum: Implications for YakA signaling and GST enzyme function.
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Curcumin suppresses members of the yakA-mediated developmental signaling pathway and delays development.
"suppressed the prestarvation marker, discoidin I, members of the yakA-mediated developmental signaling pathway, and expression of the extracellular matrix/cell adhesion proteins (DdCAD and csA)"
YakA, a protein kinase required for the transition from growth to development in Dictyostelium.
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Purified recombinant YakA phosphorylates myelin basic protein in vitro, demonstrating protein kinase activity.
"Purified YakA expressed in E. coli is able to phosphorylate myelin basic protein"
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yakA-null cells are smaller with an accelerated cell cycle, and conditional YakA expression arrests the cell cycle and promotes developmental gene expression.
"Expression of yakA from a conditional promoter causes cell-cycle arrest in nutrient-rich medium and promotes developmental events, such as the expression of genes required for cAMP signaling"