PA0011 (HtrB1, Q9I7B5) review notes

Review session 2026-11-05 (PseudoCAP IBA-seed protocol, tier 2)

Fetched with just fetch-gene PSEAE Q9I7B5 --alias PA0011; accession matches the worklist. No
deep-research provider used. PMID:26223882 and PMID:22146126 are abstract-only.

Literature

PMID:26223882
PMID:22146126
Basis of the heat, antibiotic and osmotic stress IMP rows: an indirect envelope phenotype.

Annotation decisions

ACCEPT: GO:0016747 (IDA), GO:0009245 (IDA), GO:0005886 (IEA).
TOO_GENERAL: GO:0016746 (IBA, IEA), GO:0016740, GO:0009247 (IBA, IEA), GO:0016020 (IBA, IEA).
MARK_AS_OVER_ANNOTATED: GO:0034605, GO:0071236, GO:0071470 (IMP).
Action counts: ACCEPT 3, TOO_GENERAL 7, MARK_AS_OVER_ANNOTATED 3. No source defects.

PseudoCAP IBA-seed assessment

Shares PTN004745460 with lpxL (PA3242); verdicts kept consistent, see lpxL notes. No node-level defect.

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN004745460	GO:0016746 acyltransferase activity	6	36 (22 taxa)	GO:0016747, IDA, PMID:26223882 (PseudoCAP)	SOUND	Abstract states HtrB1 is responsible for site-specific lipid A acylation. Assay type not checked (abstract only).	E. coli LpxL P0ACV0, LpxM P24205, LpxP P0ACV2, M. tuberculosis PatA P9WMB5, lpxL Q9HYZ8	Yes
PTN004745460	GO:0009247 glycolipid biosynthetic process	6	23 (21 taxa)	GO:0009245, IDA, PMID:26223882 (PseudoCAP)	SOUND	Lipid A is a glycolipid.	as above	Yes