Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.
Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.
Absence of PPP2R1A mutations in Wilms tumor.
Protein phosphatase 2A interacts with and directly dephosphorylates RelA.
Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.
Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein.
Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus.
A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130.
Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.
Single-step Strep-tag purification for the isolation and identification of protein complexes from mammalian cells.
Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A.
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A.
Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt.
Towards a proteome-scale map of the human protein-protein interaction network.
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.
Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes.
A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.
B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK.
Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.
Interaction of nucleoredoxin with protein phosphatase 2A.
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins.
Structure of the protein phosphatase 2A holoenzyme.
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B).
Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway.
Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments.
Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.
The tumor suppressor PP2A Abeta regulates the RalA GTPase.
Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.
Heterochromatin links to centromeric protection by recruiting shugoshin.
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.
Physical association of GPR54 C-terminal with protein phosphatase 2A.
An empirical framework for binary interactome mapping.
An integrated workflow for charting the human interaction proteome: insights into the PP2A system.
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.
The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.
Nuclear tau, a key player in neuronal DNA protection.
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.
Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors.
Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET.
Toward an understanding of the protein interaction network of the human liver.
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A.
Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway.
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.
STRIPAK components determine mode of cancer cell migration and metastasis.
The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
FAM122A, a new endogenous inhibitor of protein phosphatase 2A.
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase).
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Roles of tau protein in health and disease.
The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit.
MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.
SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis.
De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.
Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.
A reference map of the human binary protein interactome.
INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
IRF1 Promotes the Innate Immune Response to Viral Infection by Enhancing the Activation of IRF3.
CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress.
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Cryo-EM structure of the Hippo signaling integrator human STRIPAK.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Structural basis of Integrator-mediated transcription regulation.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Structural basis of INTAC-regulated transcription.
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II.
Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype-Phenotype Analysis in Neurodevelopmentally Delayed Patients.
Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Structural basis of Integrator-dependent RNA polymerase II termination.
Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.
Identification of a new family of protein phosphatase 2A regulatory subunits.
Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing.
Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle.
Alpha 4 associates with protein phosphatases 2A, 4, and 6.
Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens.
SPRY2 translocates to the plasma membrane
SRC phosphorylates SPRY2 on Y55 and Y227
PPA2A dephosphorylates SPRY2
PPTN11 dephosphorylates SPRY2
PP2A dephosphorylates BANF1
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
SMG6 hydrolyzes mRNA with premature termination codon
SPRY2 is phosphorylated by phosphorylated MNK1
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
PP2A dephosphorylates serine-127 of YAP1