Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic Gene Ontology annotation based on Rhea mapping

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.

Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation.

Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome.

Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations.

Importance of glutamate 279 for the coenzyme binding of human glutamate dehydrogenase.

Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.

Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.

Identification of ADP-ribosylation site in human glutamate dehydrogenase isozymes.

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.

Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.

Architecture of the human interactome defines protein communities and disease networks.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme.

Multimodal cell maps as a foundation for structural and functional genomics.

Abnormal glutamate metabolism in an adult-onset degenerative neurological disorder.

SIRT4 transfers ADPRib to GLUD

SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2

alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)

glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)

LONP1 degrades mitochondrial matrix proteins

LONP1 binds mitochondrial matrix proteins