ARPP21 review notes

Sources

• Affinage: trust gates clear.
• Key papers:
• PMID:29581509 (full text): iCLIP shows ARPP21 binds U-rich 3' UTR sequences. It opposes miR-128 via eIF4F and promotes dendritic branching in mouse cortical neurons. Tagged mouse proteins were expressed in HEK-293T cells.
• PMID:38467629 (full text): direct R3H-domain RNA binding in mouse thymocytes.
• Mouse Arpp21 (Q9DCB4) donor rows (QuickGO) include IDA cytoplasm (PMID:29581509) and IDA mRNA 3'-UTR binding (PMID:38467629).

Decisions

• ACCEPT: cytoplasm (IBA, IEA).
• MODIFY: nucleic acid binding (InterPro R3H IEA) → mRNA 3'-UTR binding.
• NEW: positive regulation of dendrite morphogenesis (ISO from mouse, PMID:29581509).

2026-10-04 review round (PR #4206)

• QuickGO (2026-10-04): mouse Arpp21 (Q9DCB4) has no GO:0050775 row from MGI. Its MGI rows are 3-UTR binding, cytoplasm and thymocyte processes (PMID:38467629). The dendrite ISO rests directly on the PMID:29581509 mouse IUE experiments.
• Added GO:0045727 PMID:29581509.