Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniPathway vocabulary mapping
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The SCF Complex Is Essential to Maintain Genome and Chromosome Stability.
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex
CAND1 binds cytosolic CRL E3 ubiquitin ligases
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex
Transfer of Ub from E2 to substrate and release of E2
Release of E3 from polyubiquitinated substrate
Polyubiquitination of substrate
Interaction of E3 with substrate and E2-Ub complex
Falcon deep research report for human FBXO30
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FBXO30 is a substrate-recognition F-box adaptor of SCF/CUL1-RING ubiquitin ligase complexes, conferring specificity for ubiquitin-dependent proteasomal turnover rather than catalyzing a small-molecule reaction.
"it is not an enzyme that catalyzes a small-molecule reaction; rather, it confers target specificity for **ubiquitylation leading to proteasomal degradation**."
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In human cells FBXO30 ubiquitinates RARG, positively regulating BMP signaling, and promotes proteasomal degradation of HIF-1A.
"Human work directly demonstrates FBXO30-mediated ubiquitylation of **RARγ** and proteasome-dependent regulation of **HIF-1α**"
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FBXO30 is predominantly cytoplasmic in human cells and colocalizes with its RARG substrate.
"A human study reports FBXO30 is **predominantly cytoplasmic**, and FBXO30 and RARγ show **cytoplasmic colocalization** by immunofluorescence"
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In the mouse ortholog FBXO30 binds SKP1 and CUL1 and ubiquitinates the mitotic kinesin Eg5/KIF11 and the stem-loop binding protein SLBP.
"Fbxo30 physically associates with **Skp1 and Cul1** and targets the mitotic kinesin **Eg5/KIF11** for ubiquitin-dependent regulation."