GLR1 notes (YPL091W, P41921)

• Glutathione reductase EC 1.8.1.7, FAD, homodimer [UniProt:P41921 "Reaction=2 glutathione + NADP(+) = glutathione disulfide + NADPH +"]; two isoforms by alternative initiation [UniProt:P41921 "Event=Alternative initiation; Named isoforms=2;"].
• Cloning: PMID:7737505
• Cytosolic redox: PMID:23242256
• Stationary phase / Yap1: PMID:8951820
• Localisation: cytosol + nucleus by GFP PMID:23613772; peroxisomes and mitochondria PMID:36164978.
• Glutathionylation: PMID:20074363

Curation observations

• protein glutathionylation IGI marked over-annotated (indirect, co-overexpression with Grx1).
• Nucleus and peroxisome kept non-core; cytosol and mitochondrion core.