Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1.
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GL3 directly interacts with GL1 in yeast and plant overexpression assays; GL1-TTG1 direct binding was not detected in the yeast assay.
"Yeast two-hybrid assays indicate that GL3 participates in physical
interactions with GL1, TTG1, and itself, but that GL1 and TTG1 do not interact."
Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
Roles of the GLABROUS1 and TRANSPARENT TESTA GLABRA Genes in Arabidopsis Trichome Development.
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Coexpression experiments place GL1 in shoot epidermal trichome cell-fate control.
"the constitutive expression of both
GL1 and R in the same plant caused trichomes to develop on all shoot epidermal
surfaces."
A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis.
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EGL3 interacts with GL1 in the redundant bHLH network supporting trichome initiation.
"Yeast two-hybrid and plant overexpression studies show that EGL3, like
GL3, interacts with TTG1, the myb proteins GL1, PAP1 and 2, CPC and TRY"
A contradictory GLABRA3 allele helps define gene interactions controlling trichome development in Arabidopsis.
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The gl3-sst allele reduces interaction with GL1; TRY inhibits GL1-GL3 association, and functional GFP-GL1 localizes to trichome nuclei.
"Analysis of plants expressing functional GFP-tagged versions of GL1, GL3 and TRY
show that the proteins are localized in trichome nuclei."
Comparison of TRY and the closely related At1g01380 gene in controlling Arabidopsis trichome patterning.
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The R3-MYB inhibitor At1g01380 inhibits GL1-GL3 interaction; altered GL1-GL3 affinity in gl3-sst is associated with trichome clustering.
"At1g01380 protein can inhibit the
interaction between the positive trichome regulators GL1 and GL3"
The TTG1-bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of regulatory loci.
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GL1 binds regulatory promoters controlling trichome differentiation and lateral inhibition.
"In
vivo binding of the R2R3-MYB protein GLABRA1 (GL1) to the promoters of GLABRA2
(GL2), TRANSPARENT TESTA GLABRA2 (TTG2), CAPRICE (CPC) and ENHANCER OF
TRIPTYCHON AND CAPRICE1 (ETC1) establishes that these genes are major
transcriptional targets for the TTG1-bHLH-MYB regulatory complex."
The Jasmonate-ZIM-domain proteins interact with the WD-Repeat/bHLH/MYB complexes to regulate Jasmonate-mediated anthocyanin accumulation and trichome initiation in Arabidopsis thaliana.
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JAZ repressors bind the GL1-containing transcriptional module, connecting jasmonate-dependent relief of repression to trichome initiation.
"JAZ proteins interact with bHLH (Transparent Testa8, Glabra3
[GL3], and Enhancer of Glabra3 [EGL3]) and R2R3 MYB transcription factors (MYB75
and Glabra1)"
Arabidopsis DELLA and JAZ proteins bind the WD-repeat/bHLH/MYB complex to modulate gibberellin and jasmonate signaling synergy.
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DELLA and JAZ repressors bind GL1 and bHLH partners, coupling GA and JA signaling to activation of trichome developmental transcription.
"DELLAs and JAZs interact with bHLH factors (EGL3 and GL3) and MYB factor (GL1), essential components of the WD-repeat/bHLH/MYB complex, to repress their transcription activity"
Quantitative insight into the combinatorial interactions within MYB-BHLH-WD complex in Arabidopsis thaliana.
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Purified-protein quartz-crystal microbalance experiments measure GL1 association with GL3 and PAP1; these in vitro affinities do not establish an anthocyanin biosynthetic role for GL1.
"Dissociation constants were measured by applying nonlinear fit on Langmuir formula (Fig 1D), resulting in the dissociation constants (KD) of GL3 and GL1, GL3 and PAP1, and PAP1 and GL1, which were 9.53 ± 7.52 µM, 0.29 ± 0.20 µM, and 0.049 ± 0.04 µM, respectively (average of three independent experiments)"
Cytotoxic and enterotoxic activities of Campylobacter jejuni are not specified by tetracycline resistance plasmids pMAK175 and pUA466.
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This bacterial plasmid paper cannot establish the intended GL1 fruit-development phenotype.
"The 45-kilobase tetracycline resistance plasmids pMAK175 and pUA466 from
Campylobacter jejuni were examined using curing and mating experiments."
MYB transcription factors drive evolutionary innovations in Arabidopsis fruit trichome patterning.
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A structural GL1 allele, together with cis-regulatory TCL1 and TRY alleles, underlies natural trichome development on fruits and pedicels in Iberian relict accessions.
"Functional characterization of these three loci revealed cis-regulatory mutations in TRICHOMELESS1 and TRIPTYCHON, as well as a structural mutation in GLABRA1."
Gibberellins promote trichome formation by Up-regulating GLABROUS1 in arabidopsis.
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GL1 acts downstream of gibberellin signaling in trichome development.
"In the double mutant the
gl1-1 glabrous phenotype is epistatic to the spy-5 phenotype, suggesting that
GL1 acts downstream of the GA signal transduction pathway."
Falcon deep research for Arabidopsis GL1
UniProt record for Arabidopsis GL1
PANTHER PTHR47999 family entries for Arabidopsis GL1