Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.
The Polycomb group protein EZH2 directly controls DNA methylation.
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells.
Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA.
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.
Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.
Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells.
Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain.
cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus.
Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.
A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells.
Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs.
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.
Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.
A proteome-scale map of the human interactome network.
Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport.
Structural basis for DNMT3A-mediated de novo DNA methylation.
Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PRC2 recruits DNA methyltransferases
DNMT1,3A,3B:PRC2 methylates cytosine and histone H3
DNMT3A binds Me2sR4-HIST1H4
The GSDME gene promoter is hypermethylated
Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue.