FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells.
Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651.
Functional association between SLAP-130 and SLP-76 in Jurkat T cells.
Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.
Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein.
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
A novel S3S-TAP-tag for the isolation of T-cell interaction partners of adhesion and degranulation promoting adaptor protein.
SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.
Improved two-dimensional reversed phase-reversed phase LC-MS/MS approach for identification of peptide-protein interactions.
Phospho-tyrosine dependent protein-protein interaction network.
ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion.
Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.
FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells.
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1.
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.
TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.
Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells.
Role for ADAP in shear flow-induced platelet mechanotransduction.
PRAM-1 is required for optimal integrin-dependent neutrophil function.
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55.
Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Structure of a helically extended SH3 domain of the T cell adapter protein ADAP.
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
The DNA sequence and comparative analysis of human chromosome 5.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells.
Phosphoproteome of resting human platelets.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Recessive thrombocytopenia likely due to a homozygous pathogenic variant in the FYB gene: case report.
Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia.
Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases.
Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130.
SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55.
The helically extended SH3 domain of the T cell adaptor protein ADAP is a novel lipid interaction domain.
Lipid-binding hSH3 domains in immune cell adapter proteins.
p-4Y-SIRPA:CD47:SKAP2 binds FYB
Signal regulatory protein family interactions
Generation of second messenger molecules