Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

T-box gene tbx5 is essential for formation of the pectoral limb bud.

The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome.

The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10.

The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation.

sall4 acts downstream of tbx5 and is required for pectoral fin outgrowth.

Foxn4 directly regulates tbx2b expression and atrioventricular canal formation.

Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish.

Cascade effect of cardiac myogenesis gene expression during cardiac looping in tbx5 knockdown zebrafish embryos.

Physical interaction between TBX5 and MEF2C is required for early heart development.

Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation.

Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish.

Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo.

Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos.

The paracrine effect of exogenous growth hormone alleviates dysmorphogenesis caused by tbx5 deficiency in zebrafish (Danio rerio) embryos.

MicroRNA 218 mediates the effects of Tbx5a over-expression on zebrafish heart development.

Zebrafish tbx5 paralogs demonstrate independent essential requirements in cardiac and pectoral fin development.

Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish.

Distinct tissue-specific requirements for the zebrafish tbx5 genes during heart, retina and pectoral fin development.

MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome.

A TBX5 3'UTR variant increases the risk of congenital heart disease in the Han Chinese population.

Post-transcriptional Modulation of Sphingosine-1-Phosphate Receptor 1 by miR-19a Affects Cardiovascular Development in Zebrafish.

Analysis of a conditional gene trap reveals that tbx5a is required for heart regeneration in zebrafish.

Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.

A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes.

Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process.

Identification and characterisation of the developmental expression pattern of tbx5b, a novel tbx5 gene in zebrafish.

A transcriptomics analysis of the Tbx5 paralogues in zebrafish.

Tbx5a and Tbx5b paralogues act in combination to control separate vectors of migration in the fin field of zebrafish.

Anterior lateral plate mesoderm gives rise to multiple tissues and requires tbx5a function in left-right asymmetry, migration dynamics, and cell specification of late-addition cardiac cells.

Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration.

Regulatory evolution of Tbx5 and the origin of paired appendages.

Zebrafish: unraveling genetic complexity through duplicated genes.