Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.
Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.
Expression of RGS2, RGS4 and RGS7 in the developing postnatal brain.
High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons.
RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion.
CASK associates with glutamate receptor interacting protein and signaling molecules.
RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia.
Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum.
RGS2 and RGS4 modulate melatonin-induced potentiation of glycine currents in rat retinal ganglion cells.
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The donor study measures glycine-evoked currents, which do not establish glycine import.
"using immunohistochemistry, Western
blot analysis and whole-cell patch-clamp techniques"
RGS4 exerts inhibitory activities on the signaling of dopamine D2 receptor and D3 receptor through the N-terminal region.
RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate.
RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents.
Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors.
The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Chronic intermittent ethanol exposure selectively alters the expression of Gα subunit isoforms and RGS subtypes in rat prefrontal cortex.
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits.
Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.
RGS4 inhibits G-protein signaling in cardiomyocytes.
GPCR downstream signalling
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3
Active G alpha (q) binds RGS proteins
Active G alpha (i)–i1/i2/i3 binds RGS proteins
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated
G alpha (q) in G (q):RGS complex is inactivated
G alpha (q):RGS dissociates to inactive G alpha (q)