Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking.
CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.
Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking.
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding.
The protein network of HIV budding.
Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.
ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles.
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A.
Structural and mechanistic studies of VPS4 proteins.
Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1.
A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.
Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release.
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.
Phosphatidylethanolamine, a limiting factor of autophagy in yeast strains bearing a defect in the carboxypeptidase Y pathway of vacuolar targeting.
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
ESCRT-III recognition by VPS4 ATPases.
Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction.
Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding.
Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly.
Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding.
Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B.
Biochemical analyses of human IST1 and its function in cytokinesis.
Essential role of hIST1 in cytokinesis.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Membrane scission by the ESCRT-III complex.
Three-dimensional structure of AAA ATPase Vps4: advancing structural insights into the mechanisms of endosomal sorting and enveloped virus budding.
Membrane budding and scission by the ESCRT machinery: it's all in the neck.
Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.
The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes.
Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15.
ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting.
Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.
Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
ESCRT requirements for EIAV budding.
ESCRT machinery is required for plasma membrane repair.
ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4.
Structure of cellular ESCRT-III spirals and their relationship to HIV budding.
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.
ESCRT-III controls nuclear envelope reformation.
∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.
LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.
Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.
Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage.
The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment.
Nuclear Envelope (NE) Reassembly
Recruitment Of HIV Virion Budding Machinery
HCMV Formation of Final Envelopment Complex
VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
UniProt entry for VPS4A (Q9UN37)
Local curation notes for VPS4A