Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
p62 functions as a p38 MAP kinase regulator.
Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling.
Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone.
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
A human protein-protein interaction network: a resource for annotating the proteome.
Towards a proteome-scale map of the human protein-protein interaction network.
The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation.
Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover.
Defining the human deubiquitinating enzyme interaction landscape.
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.
Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis.
Nix is a selective autophagy receptor for mitochondrial clearance.
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1.
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha.
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy.
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.
Network organization of the human autophagy system.
NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo.
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both.
Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance.
A directed protein interaction network for investigating intracellular signal transduction.
Toward an understanding of the protein interaction network of the human liver.
Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.
TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells.
Global landscape of HIV-human protein complexes.
TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.
The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins.
MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.
Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.
Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.
Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression.
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.
A proteome-scale map of the human interactome network.
Disruption of FAT10-MAD2 binding inhibits tumor progression.
Huntingtin functions as a scaffold for selective macroautophagy.
Widespread macromolecular interaction perturbations in human genetic disorders.
Quantitative interaction proteomics of neurodegenerative disease proteins.
ATM functions at the peroxisome to induce pexophagy in response to ROS.
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells.
Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.
Autophagy mediates degradation of nuclear lamina.
ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress.
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport.
TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy.
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.
The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.
TRIM23 mediates virus-induced autophagy via activation of TBK1.
p62 filaments capture and present ubiquitinated cargos for autophagy.
Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation.
P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.
The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy.
Intrinsically Disordered Protein TEX264 Mediates ER-phagy.
A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display.
p62 Negatively Regulates TLR4 Signaling via Functional Regulation of the TRAF6-ECSIT Complex.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome.
Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Cytoplasmic short linear motifs in ACE2 and integrin β(3) link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.
Global Proximity Interactome of the Human Macroautophagy Pathway.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.
The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.
Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.
The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection.
Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.
P62/SQSTM1 binds with claudin-2 to target for selective autophagy in stressed intestinal epithelium.
S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy.
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.
Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain.
p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins.
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.
p62 recruits an atypical PKC
p62 is recruited and forms a complex with TRAF6
IKKbeta phosphorylates IkB causing NF-kB to dissociate
Polyubiquitinated NRIF migrates to the nucleus
Polyubiquitinated NRIF binds to p62 (Sequestosome)
NRIF signals cell death from the nucleus
TRAF6 is auto-ubiquitinated
p62 links damaged mitochondria to LC3
LC3 binds the autophagosome membrane Atg5-Atg12 complex
p62 binds ubiquitinated mitochondrial substrates
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
NBR1 binds ATM:Ub-p-PEX5:SQSTM1
SQSTM1 binds ATM dimer:Ub-p-PEX5
TRIM21 ubiquitinates SQSTM1
NFE2L2-dependent SQSTM1 gene expression
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer
HBV X protein binds SQSTM1 oligomer
SQSTM1 oligomer is phosphorylated
CUL3:RBX1 ubiquitinates KEAP1
RBX1:CUL3 dissociates from forming autophagosome
MAP1LC3B binds KEAP1 and SQSTM1
SESN1,SESN1 bind SQSTM1 and KEAP1