Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Molecular cloning and expression of biologically active human glia maturation factor-beta.
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Early cloning work associated GMFB with neural differentiation and maintenance.
"Glia maturation factor-beta, a protein found in the brains of all vertebrates thus far examined, appears to play a role in the differentiation, maintenance, and regeneration of the nervous system."
Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor.
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GMFB is phosphorylated by kinases and is not itself a kinase.
"recombinant glia maturation factor (GMF), a 17-kD brain protein, can be phosphorylated in vitro at the serine residue by protein kinase C (PKC), protein kinase A (PKA), and casein kinase II (CKII)"
In vitro inhibition of MAP kinase (ERK1/ERK2) activity by phosphorylated glia maturation factor (GMF).
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Phosphorylated GMF inhibited ERK1/2 activity in vitro.
"recombinant glia maturation factor (GMF), a 17-kDa brain protein, inhibits the activity of mitogen-activated protein (MAP) kinase in the test tube assay"
In vitro enhancement of p38 mitogen-activated protein kinase activity by phosphorylated glia maturation factor.
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Phosphorylated GMF enhanced p38 MAP kinase activity in vitro.
"PKA-phosphorylated GMF strongly enhances the activity of a related but distinct subfamily of MAP kinase, the p38 MAP kinase"
UniProt text export for GMFB (P60983)
Falcon deep research report for GMFB
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Falcon research supports GMFB as an Arp2/3-centered actin network remodeling factor.
"Current consensus from the cited review and recent primary work is that GMF-beta is an actin-network remodeling factor that binds the Arp2/3 complex"