Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi.
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SBF/MBF DNA-binding subunits (KilA-N/APSES) arose in fungi from a viral KilA-N protein and have no eukaryotic homologs outside fungi; animals use E2F-Rb for the G1/S transition.
"We were unable to find any eukaryotic homologs of SBF or Whi5 outside of fungi, with a few exceptions related to DNA viruses that we discuss later."
Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons.
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Rate-ratio screen of GOA flagged taxon-inappropriate annotations; IBA was the largest error source. Its supplementary list includes the MBF/SBF transcription complex IBAs on this protein.
"Importantly, 56% of the misannotations are 'Inferred from Biological aspect of Ancestor (IBA)'"
Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos.
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The C. elegans chromodomain protein CEC-4 binds methylated H3K9 and localizes at the nuclear envelope; provides context for the CEC chromodomain family, not data on CEC-10.
"CEC-4 binds preferentially mono-, di-, or tri-methylated H3K9 and localizes at the nuclear envelope independently of H3K9 methylation and nuclear lamin."
UniProt entry Q9N4L7 (cec-10, unreviewed)
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N-terminal chromodomain (49-110), single ankyrin repeat (520-552), PANTHER PTHR43828:SF3 and InterPro IPR051642 SWI6-like family signature; no KilA-N/APSES domain listed.
"InterPro; IPR051642; SWI6-like."
cec-10 versus the fungal SBF/MBF family - domain and alignment check
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CEC-10 lacks the KilA-N/APSES DNA-binding domain of the MBF/SBF DNA-binding subunits and shows only weak pairwise similarity (Z 1.9-5.5) to the six yeast seeds of PTN000917496.
"CEC-10 has no KilA-N / APSES-type HTH DNA-binding domain (IPR003163, IPR018004, PF04383)."