Annotation inferences using phylogenetic trees

The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.

CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease.

Genetic and physical interaction between the NPHP5 and NPHP6 gene products.

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis.

Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres.

Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis.

The centriolar satellite protein Cep131 is important for genome stability.

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.

Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis.

CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.

BBS mutations modify phenotypic expression of CEP290-related ciliopathies.

The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.

The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.

Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability.

A proteome-scale map of the human interactome network.

Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.

The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking.

Architecture of the human interactome defines protein communities and disease networks.

A reference map of the human binary protein interactome.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

CCDC66 regulates primary cilium length and signaling via interactions with transition zone and axonemal proteins.

Exocytosis of specific granule lumen proteins

The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Proteomic characterization of the human centrosome by protein correlation profiling.

Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis.

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.

AJUBA facilitates AURKA autophosphorylation

AJUBA binds centrosome-associated AURKA

AURKA phosphorylates PLK1

BORA binds PLK1 and AURKA

Plk1-mediated phosphorylation of Nlp

Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome

Loss of C-Nap-1 from centrosomes

Dissociation of Phospho-Nlp from the centrosome

Recruitment of Plk1 to centrosomes

Association of NuMA with microtubules

Recruitment of CDK11p58 to the centrosomes

Translocation of NuMA to the centrosomes

RAB3IP stimulates nucleotide exchange on RAB8A

C2CD3 binds the mother centriole

C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole

CP110 and CEP97 dissociate from the centriole

The distal appendage proteins recruit TTBK2

Recruitment of transition zone proteins

MARK4 binds ODF2 in the centriole

CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal

TPX2 binds AURKA at centrosomes

TPX2 promotes AURKA autophosphorylation

MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone.

Defining the membrane proteome of NK cells.

Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration.

Mutations in human homologue of chicken talpid3 gene (KIAA0586) cause a hybrid ciliopathy with overlapping features of Jeune and Joubert syndromes.

In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse.

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.

Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors.

CEP290 bounded source evidence and superseded authored-annotation provenance