NECTIN4 curation notes

Deep research (falcon/perplexity-lite) unavailable; notes from UniProt Q96NY8 and cached papers.

• Topology: signal 1-31, extracellular 32-349 (IgV-IgC-IgC), TM 350-370, cytoplasmic 371-510 (afadin-binding C-terminus).
• Adherens junctions with afadin (UniProt, PMID:11544254); homophilic and nectin-1 heterophilic adhesion
  PMID:22902367.
• Measles virus epithelial receptor via IgV domain [PMID:22048310; PMID:23202587].
• TIGIT ligand inhibiting NK cells PMID:32503945 - single-lab finding, non-core.
• ADAM17 shedding of entire ectodomain PMID:15784625.

Localization conclusion: plasma membrane (adherens junctions, lateral membrane), single-pass type I;
ectodomain extracellular and surface-accessible (ADC target); shed ectodomain in serum.