Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic Gene Ontology annotation based on Rhea mapping

Combined Automated Annotation using Multiple IEA Methods

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.

Crystal structure of the Golgi casein kinase.

A secretory kinase complex regulates extracellular protein phosphorylation.

A Single Kinase Generates the Majority of the Secreted Phosphoproteome.

Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α.

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.

Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization.

Post-translational protein modification

FAM20C phosphorylates FAM20C substrates

Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation.

Whole-Exome sequencing identifies FAM20A mutations as a cause of amelogenesis imperfecta and gingival hyperplasia syndrome.

Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice.

The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins.

UniProtKB Q8IXL6 (FA20C_HUMAN): extracellular serine/threonine protein kinase FAM20C