ALE1 (YOR175C / LPT1 / SLC4) notes

UniProt Q08548; module triacylglycerol_biosynthesis (MBOAT LPAAT annoton, GO:0003841).

Evidence journal

• Major LPEAT; MAM enriched PMID:17652094, PMID:17652094.
• Sole LPCAT after lyso-PC import PMID:17951629.
• Highest activity with lysoPC PMID:26643989.
• Second LPAAT with Slc1 PMID:17675291; PMID:17890783.
• LPAAT is secondary in vitro PMID:18154737.
• Lyso-PAF acetyltransferase PMID:17890783.
• PC deacylation/reacylation pathway PMID:30514764.

Observations for module

• Module types Ale1 by LPAAT (GO:0003841); biologically its dominant activity is LPCAT/LPEAT (remodeling). LPAAT is a genuine but secondary activity; fine as a TAG-module role but should be flagged as secondary.