Manual review completed for Arabidopsis thaliana CLV1 (Q9SYQ8), using the
seeded GOA, UniProt record, Falcon deep research, cached publications, and the
PANTHER PTHR48056 plant LRR-RLK family context.
Core synthesis: CLV1 is a plasma membrane LRR receptor-like Ser/Thr kinase that
binds CLV3-family CLE peptides and signals through CLV1/BAM/CIK and downstream
RLCK modules to restrict meristem stem cell proliferation. The original cloning
paper supports the mutant phenotype and receptor-kinase identity
[PMID:9160749 "Arabidopsis plants homozygous for mutations at the CLAVATA1
(CLV1) locus accumulate excess undifferentiated cells"; "It encodes a putative
receptor kinase, suggesting a role in signal transduction"]. CLV3-dependent
signaling complex assembly is supported by the 450-kD complex paper
PMID:10072399.
Kinase activity is supported by KAPP studies and newer RLCK work. KAPP binds
autophosphorylated CLV1 and co-immunoprecipitates with CLV1 from meristematic
tissue PMID:9701578. CLV1 phosphorylates itself and KAPP PMID:9294234. PBL34/35/36 interact with
CLV1/BAM/CIK proteins and are phosphorylated by CLV1/BAM1 PMID:34935965.
Binding curation: all generic GO:0005515 protein binding rows were treated as
non-core and, where evidence was clear, modified to a more informative term:
protein phosphatase binding for KAPP, peptide hormone binding for CLV3/CLE
ligands, receptor Ser/Thr kinase binding for CLV1/BAM/CIK/CRN receptor-module
interactions, kinase binding for MAZ/Pti1-like and PBL RLCK partners, and
14-3-3 protein binding for the TAP-MS 14-3-3 interaction. The PMID:29320478
IntAct row was left UNDECIDED because the cached article text describes the
large LRR-RK network but not the CLV1-specific partners.
Localization curation: plasma membrane is accepted as the active signaling
location PMID:21051944. Plant-type vacuole is kept as non-core because CLV3 causes ligand-
dependent trafficking of CLV1 to lytic vacuoles PMID:21333538. Plasmodesma is kept as non-core for
root meristem context PMID:23394827.