Annotation inferences using phylogenetic trees
Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death.
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum.
Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.
The metallopeptide antibiotic bacitracin inhibits interleukin-12 alphabeta and beta2 secretion.
Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins.
pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family.
Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation.
Disulphide production by Ero1α-PDI relay is rapid and effectively regulated.
Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum.
The endoplasmic reticulum sulfhydryl oxidase Ero1β drives efficient oxidative protein folding with loose regulation.
Protein disulfide isomerase isomerizes non-native disulfide bonds in human proinsulin independent of its peptide-binding activity.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry.
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LGALS9 retains PDI at the Th2 cell surface, increasing disulfide reductase activity, altering plasma-membrane redox state, enhancing T-cell migration; cell-surface PDI also promotes HIV-1 entry and binds integrin.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking.
Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia.
Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation.
Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization.
Protein disulfide isomerase directly interacts with β-actin Cys374 and regulates cytoskeleton reorganization.
Novel missense MTTP gene mutations causing abetalipoproteinemia.
Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function.
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.
Characterization of the human gene for a polypeptide that acts both as the beta subunit of prolyl 4-hydroxylase and as protein disulfide isomerase.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene.
Binding of Host Cell Surface Protein Disulfide Isomerase by Anaplasma phagocytophilum Asp14 Enables Pathogen Infection.
Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.
A reference map of the human binary protein interactome.
Phosphorylated tau interactome in the human Alzheimer's disease brain.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Multimodal cell maps as a foundation for structural and functional genomics.
Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: Insulin processing.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: Interleukin-12 signaling.
Reactome: Interleukin-23 signaling.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
Reactome: PDI in ER lumen.
UniProt entry P07237 (PDIA1_HUMAN), Protein disulfide-isomerase / P4HB
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Multifunctional ER thioredoxin-fold protein that catalyzes formation/breakage/rearrangement of disulfide bonds (PDI activity, EC 5.3.4.1), acts as thiol oxidase/reductase and redox-dependent chaperone, is the structural beta-subunit of prolyl 4-hydroxylase and of the MTTP complex, regulates ERN1/IRE1A, and has cell-surface/cytoskeletal moonlighting roles.