SDH2 (YLL041C, P21801) notes

Evidence journal for the review. No paid deep research was run; sources are the UniProt record and cached publications.

• Iron-sulfur (Ip) subunit of complex II; forms the catalytic dimer with Sdh1p [UniProt:P21801 "SDH1 and SDH2 form the catalytic dimer."].
• Electron relay: PMID:24954416; PMID:9822678
• Architecture: PMID:24954416
• Required for the holocomplex: PMID:24954416.
• Genetics: PMID:16232921.
• Membrane association depends on Sdh1p: PMID:1939170
• Cofactors (UniProt, by similarity): one [2Fe-2S], one [3Fe-4S], one [4Fe-4S]. Only 2Fe-2S binding and generic Fe-S binding are in GOA; 3Fe-4S (GO:0051538) and 4Fe-4S (GO:0051539) binding are not annotated (possible addition).

Curation decisions
- The three IPI 'protein binding' rows (all with Sdh1p) were removed as uninformative; complex membership is captured by GO:0045273.
- Core MF: electron transfer activity (subunit-specific), contributes_to SQR activity GO:0008177. The existing 'enables' GO:0008177 rows (IDA 1957, IMP/IGI 2000) were accepted rather than second-guessed.
- Generic 'protein-containing complex' (RCA) and 'oxidoreductase activity' (IEA) were changed to the specific terms.