Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans.
-
FKH-2 regulates kap-1 expression specifically in the AWB neurons.
"FKH-2 acts synergistically with the OTX homeodomain protein CEH-37 ( Lanjuin et al , 2003 ) to specify AWB cell fate, but in addition, regulates the expression of broadly expressed ciliary genes such as kap-1 in an AWB-specific manner."
-
In AWB cilia OSM-3 moves independently of kinesin-II.
"We show that unlike in the ASH/ASI cilia, the OSM-3 kinesin moves independently of the kinesin-II motor in the AWB cilia."
WormBase gene description for kap-1 (worm)
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Role of a class DHC1b dynein in retrograde transport of IFT motors and IFT raft particles along cilia, but not dendrites, in chemosensory neurons of living Caenorhabditis elegans.
Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors.
Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner.
A mutual co-recognition mechanism ensures the proper assembly of heterotrimeric kinesin-2 for intraflagellar transport.
Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia.
C. elegans KLP-11/OSM-3/KAP-1: orthologs of the sea urchin kinesin-II, and mouse KIF3A/KIFB/KAP3 kinesin complexes.