Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones.
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ERC1 isoforms are alternatively spliced; ERC1a is ubiquitous and cytosolic, ERC1b is brain-specific and localizes to active zones. Both bind Rab6, but only ERC1b binds RIM.
"ERC1a is expressed ubiquitously as a cytosolic protein outside of brain; ERC1b is detectable only in brain, where it is both a cytosolic protein and an insoluble active zone component"
Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.
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ERC proteins directly interact with liprin-alpha family, and this interaction promotes presynaptic localization of liprin-alpha and active zone organization.
"liprin-alpha directly interacts with the ERC (ELKS-Rab6-interacting protein-CAST) family of proteins"
Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit.
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ELKS/ERC1 is a regulatory subunit of the IKK complex required for NF-kappaB activation. It recruits IkappaBalpha to the IKK complex.
"We identified ELKS, an essential regulatory subunit of the IKK complex. Silencing ELKS expression by RNA interference blocked induced expression of NF-kappaB target genes"
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
Large-scale mapping of human protein-protein interactions by mass spectrometry.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling.
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ERC1 localizes to centrosomes and ciliary basal bodies, and interacts with SDCCAG8 at the centrosome. This was the first demonstration of centriolar localization for ERC1.
"RABEP2 and ERC1 localize to the centrioles of non-ciliated cells...ERC1 expression was retained at the basal body of ciliated cells"
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
A central chaperone-like role for 14-3-3 proteins in human cells.