Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification of NAD(P)H quinone oxidoreductase activity in azoreductases from P. aeruginosa: azoreductases and NAD(P)H quinone oxidoreductases belong to the same FMN-dependent superfamily of enzymes.
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Purified paAzoR1, paAzoR2 and paAzoR3 reduce quinones, at rates far above those for azo substrates.
"Rates of quinone reduction in all cases were up to two orders of magnitude higher than were observed for reduction of azo substrates"
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The three paralogs differ in quinone preference.
"paAzoR2 reduces both benzoquinones and naphthoquinones efficiently"
Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa.
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PA0785 encodes an FMN-containing azoreductase, not an acyl carrier protein phosphodiesterase.
"The purified recombinant enzyme exhibits activity corresponding to that of azoreductase but not acpD."
The Escherichia coli azoreductase AzoR Is involved in resistance to thiol-specific stress caused by electrophilic quinones.
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E. coli AzoR, the experimental seed of the family nodes, is a quinone reductase that protects against electrophilic quinones.
"These data indicated that AzoR is a quinone reductase providing resistance to thiol-specific stress caused by electrophilic quinones."
A novel mechanism for azoreduction.
Activation of nitrofurazone by azoreductases: multiple activities in one enzyme.