Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
A metabotropic glutamate receptor family gene in Dictyostelium discoideum.
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GrlE/DdmGluPR is a metabotropic glutamate receptor family GPCR that localizes to the plasma membrane.
"DdmGluPR was localized to the plasma membrane of axenically grown Ax-2 cells expressed as a green fluorescent protein fusion protein"
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The alpha-carboxyl and alpha-amino glutamate-binding residues are conserved in GrlE, but the gamma-carboxyl-interacting residues are not.
"the residues of mGluRs involved in the binding of the alpha-carboxylic and alpha-amino groups of glutamate were well conserved in DdmGluPR"
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GrlE-null cells grow faster to higher densities, aggregate late, and show impaired chemotaxis toward cAMP, implicating GrlE in early development.
"DdmGluPR-null cells exhibited delayed aggregates formation upon starvation and impaired chemotaxis toward cAMP"
GABA induces terminal differentiation of Dictyostelium through a GABAB receptor.
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GrlE is the seven-transmembrane GABA(B)-like receptor for GABA in Dictyostelium.
"The receptor for GABA in Dictyostelium, GrlE, is a seven-transmembrane G-protein-coupled receptor that is most similar to GABA(B) receptors"
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GABA acting through GrlE induces release of the SDF-2 precursor AcbA from prespore cells to drive terminal spore differentiation.
"GABA induces the release of the precursor of SDF-2, AcbA, from prespore cells"
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GABA/GrlE signaling is relayed through PI3 kinase and the PKB-related kinase PkbR1, and glutamate competitively inhibits it.
"The signal transduction pathway from GABA/GrlE appears to be mediated by PI3 kinase and the PKB-related protein kinase PkbR1"