Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
A proteome-scale map of the human interactome network.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration.
-
Armcx1 is mitochondrial and enhances mitochondrial transport in RGCs.
"Armcx1 overexpression enhances mitochondrial transport in adult retinal ganglion cells (RGCs)."
-
Armcx1 co-immunoprecipitates with Miro1.
"Co-immunoprecipitation using Armcx1-HA and Miro1-Myc showed that Armcx1 interacted with Miro1 (Figure 1H), the protein linking mitochondria to the Trak1-Kinesin motor complex."
Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death.
-
Armcx1 protects against secondary brain injury after TBI.
"Armcx1 is highly expressed in the brain and is located in the mitochondrial outer membrane of neurons, where it mediates mitochondrial transport."
Armcx1 Reduces Neurological Damage Via a Mitochondrial Transport Pathway Involving Miro1 After Traumatic Brain Injury.
-
Armcx1 knockdown impairs mitochondrial transport and lowers Miro1 after TBI.
"In addition, inhibition of Armcx1 expression further led to impaired mitochondrial transport, abnormal morphology, reduced ATP levels, aggravation of neuronal apoptosis and neurological dysfunction, and decrease Miro1 expression."
The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation.
ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.
-
ALEX1 expression is lost or reduced in many carcinomas.
"Expression of ALEX1 and ALEX2 mRNA is lost or significantly reduced in human lung, prostate, colon, pancreas, and ovarian carcinomas and also in cell lines established from different human carcinomas."
UniProt entry Q9P291 (ARMX1_HUMAN)
Affinage mechanistic annotation for ARMCX1 (human)