Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Yeast flavin-containing monooxygenase generates oxidizing equivalents that control protein folding in the endoplasmic reticulum.
NCU06296 (Q7SAD4) bioinformatics: phylogenetic placement and FMO motif check
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NCU06296 is in PANTHER subfamily PTHR23023:SF292, a Pezizomycotina clade of a fungal FMO lineage that is sister (by speciation) to the whole animal FMO clade; no fungal-clade member has experimental annotation.
"No member of SF292 or of the fungal clade has experimental GO annotation; every leaf in the Fungi node is an uncharacterised genome-project entry."
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The FAD-binding motif is conserved, the NADPH-binding motif and FATGY are diverged, and no mammalian-type C-terminal membrane anchor is predicted.
"There is no predicted C-terminal membrane anchor of the mammalian type, so ER-membrane localization of mammalian FMOs should not be transferred."