Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells.

The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation.

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

RAB3IP stimulates nucleotide exchange on RAB8A

C2CD3 binds the mother centriole

C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole

CP110 and CEP97 dissociate from the centriole

The distal appendage proteins recruit TTBK2

Recruitment of transition zone proteins

MARK4 binds ODF2 in the centriole

CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body

C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.

The luminal ring protein C2CD3 acts as a radial in-to-out organizer of the distal centriole and appendages.

UniProtKB Q4AC94 C2CD3_HUMAN source record