Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.
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Original identification of AKTIP as AKT-interacting protein
"we report the identification of a novel PKB binding protein, called Ft1"
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Shows AKTIP enhances AKT phosphorylation via PDK1 interaction
"the Ft1 protein interacts directly with PKB, enhancing the phosphorylation of both of its regulatory sites by promoting its interaction with the upstream kinase PDK1"
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Reports apoptosis modulation in T lymphocytes
"modulation of PKB activity by Ft1 has a strong effect on the apoptosis susceptibility of T lymphocytes treated with glucocorticoids"
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Note - this early characterization does not reflect AKTIP's core functions identified later
Towards a proteome-scale map of the human protein-protein interaction network.
Large-scale mapping of human protein-protein interactions by mass spectrometry.
An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.
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Original identification of FHF complex (FTS/Hook/FHIP)
"we identified a new multiprotein complex, the FHF complex, containing FTS, members of the microtubule-binding Hook family of coiled-coil proteins"
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AKTIP identified as inactive E2 variant lacking catalytic function
"Fused Toes (FTS) is a member of a small group of inactive variant E2 ubiquitin-conjugating enzyme domain-containing proteins of unknown function"
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FHF associates with HOPS complex
"Hook proteins as well as FTS interact with members of both the class B and class C components of the homotypic vesicular protein sorting (HOPS) complex"
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Role in endosome/lysosome trafficking demonstrated
"Depletion of FTS by RNA interference affects both the trafficking of epidermal growth factor from early-to-late endosome/lysosomes"
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
A proteome-scale map of the human interactome network.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.
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Detailed characterization of FHF complex
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WF->AA mutation disrupts Hook interactions
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FHF-AP-4 interaction mediates ATG9A trafficking
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Documents perinuclear localization function
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes.
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AKTIP (FTS) is invariant core component of all FHF complexes
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Different Hook/FHIP combinations determine cargo specificity
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Links FHF to dynein-mediated microtubule transport
Multimodal cell maps as a foundation for structural and functional genomics.
Deep research on human AKTIP function (falcon provider)
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AKTIP functions in telomere replication support through shelterin/PCNA interactions
"AKTIP facilitates telomeric DNA replication in concert with TRF1"
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AKTIP functions as ESCRT-I adaptor at the midbody
"AKTIP binds ESCRT-I subunit VPS28 via its UEV-containing region; AKTIP recruitment to the midbody is MKLP1-dependent and CEP55-independent"
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AKTIP is a core component of the FHF complex for vesicle trafficking
"we identified a new multiprotein complex, the FHF complex, containing FTS, members of the microtubule-binding Hook family"
AKTIP-uniprot.txt evidence for AKTIP
AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
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AKTIP lacks the catalytic cysteine but directly associates with shelterin and replication factors to facilitate telomere replication.
"AKTIP is a UEV protein that contains a UBC domain lacking the catalytic cysteine that mediates ubiquitin transfer."
AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.
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AKTIP participates structurally in the ESCRT machinery and recruits abscission factors at the midbody.
"AKTIP is a component of the ESCRT I module and functions in the recruitment of
ESCRT III components required for abscission."
AKTIP loss is enriched in ERĪ±-positive breast cancer for tumorigenesis and confers endocrine resistance.
hMMS2 serves a redundant role in human PCNA polyubiquitination.
AKTIP noncatalytic K63 ubiquitination and lesion bypass: focused OpenScientist report