cut6 (SPAC56E4.04c, UniProt P78820) notes

Fetch: just fetch-gene SCHPO cut6 fetched the correct accession (ACAC_SCHPO, P78820, 2247 aa).

Naming trap

• "cut6" = cell untimely torn 6 (a mitotic mutant class) but the gene is acetyl-CoA carboxylase, orthologue of S. cerevisiae ACC1.

Evidence

• PMID:8769419.
• Mitotic phenotype: PMID:8769419;
  PMID:8769419.
• Domains/activities by similarity to S. cerevisiae ACC1 (Q00955) [UniProt:P78820]: BC, BCCP, CT; Mn2+, biotin cofactors.
• Cytoplasm/cytosol: ORFeome (PMID:16823372). Interaction with sad1 (two-hybrid, PMID:14655046; not in GOA).

GO-CAM

• gomodel:678073a900002931 has TWO cut6 ACC activities: cytosol (678073a900004003, part_of GO:0006633) and
  mitochondrion (678073a900003027, part_of GO:2001295; location from the IBA PTN000429607 only).
  The module records only the cytosolic one.

Differences from S. cerevisiae ACC1 review

• ACC1 review REMOVED the mitochondrion IBA because HFA1 is the mitochondrial ACC. S. pombe has no HFA1 counterpart,
  so here the same IBA is UNDECIDED (plausible dual targeting; no data).
• ACC1 core lists ER membrane (S. cerevisiae IDA); no S. pombe evidence, so cut6 core location is cytosol only.
• ACC1 core BP uses long-chain fatty acid biosynthetic process; here GO:0006633 (annotated) + GO:2001295.

Decisions

• Core MF GO:0003989; BP GO:2001295 + GO:0006633; cytosol.
• mitotic nuclear membrane biogenesis (IMP): KEEP_AS_NON_CORE (downstream of lipid supply).