ABTB2 notes
2026-06-03 Proteostasis PN review pass
- Started from
just fetch-gene human ABTB2, which seeded three GOA rows: InterPro-derived protein heterodimerization, IntAct/YWHAE protein binding, and HPA nucleoplasm localization.
- Deep research attempt:
just deep-research-falcon human ABTB2 --fallback perplexity-lite timed out for Falcon after 600 seconds; fallback to perplexity-lite failed with a Perplexity API quota error. Manual fallback evidence was written to ABTB2-deep-research-manual.md per project instructions.
- PN context places ABTB2 under
Ubiquitin Proteasome System > E3 ubiquitin and UBL ligases > Cul3 substrate receptor > BTB-BACK, variant > ankyrin and projects GO:1990756 ubiquitin-like ligase-substrate adaptor activity [file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_annotations.tsv "ABTB2 Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin"].
- Conservative nomenclature check: older BPOZ-2 papers are useful background for BTB/POZ substrate-adaptor biology, but I did not use them as primary ABTB2 evidence because BPOZ-2 nomenclature overlaps with ABTB1 and needs identifier-level confirmation before being projected to Q8N961. The cached TdT abstract says "BPOZ-2 bound to E3 ligase CUL3 in vitro and in vivo" PMID:18429817, but this was not the basis for the ABTB2
GO:1990756 decision.
- Direct ABTB2 evidence comes from the 2025 PDAC paper. The abstract states that "ABTB2 interacts with tumour necrosis factor receptor-associated protein 1 (TRAP1), promoting its ubiquitin-dependent degradation" PMID:41322190. The results section confirms ABTB2-TRAP1 co-IP and TRAP1 ubiquitination PMID:41322190 PMID:41322190. The discussion adds "We also found that ABTB2 interacts with cullin-3 (Figure S9)" PMID:41322190.
- Curation conclusion: accept the PN-projected
GO:1990756 for ABTB2 as a new, direct, gene-specific molecular-function annotation, but do not overstate ABTB2 as a catalytic ubiquitin ligase. Mark existing generic binding/heterodimerization rows as over-annotated and keep nucleoplasm as non-core localization.