Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked.

Inhibition of Bax channel-forming activity by Bcl-2.

A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members.

Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

The bcl-2 protein family - from discovery to drug development

Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed.

p53 has a direct apoptogenic role at the mitochondria.

The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis.

The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria.

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38).

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.

The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein Bax.

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1.

ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL.

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents.

Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2.

A short Nur77-derived peptide converts Bcl-2 from a protector to a killer.

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.

Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization.

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.

The IKK complex contributes to the induction of autophagy.

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1.

MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner.

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.

Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells.

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol.

Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4.

Control of autophagic cell death by caspase-10 in multiple myeloma.

Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer.

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.

EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance.

Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells.

Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy.

Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells.

GSK3β‑mediated Ser156 phosphorylation modulates a BH3‑like domain in BCL2L12 during TMZ‑induced apoptosis and autophagy in glioma cells.

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.

A reference map of the human binary protein interactome.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum.

Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins.

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4.

BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3.

The Bcl-2 family: roles in cell survival and oncogenesis.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Structural and biochemical analysis of Bcl-2 interaction with the hepatitis B virus protein HBx.

Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.

Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites.

Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein.

WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine.

miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma.

Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins.

The bcl-2 oncogene and apoptosis.

Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.

BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner.

Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.

[Isolation of a strain of Streptococcus pneumoniae multiresistant to antibiotics].

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains.

Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.

No death without life: vital functions of apoptotic effectors.

ASPP proteins specifically stimulate the apoptotic function of p53.

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.

BCL2 sequestration of tBID

BAD displacing tBID from BCL2

BH3-only proteins inactivating BCL2

BCL2 expression

BCL2 binding NLRP1

Estrogen-responsive BCL2 expression

BCL2 expression downstream of ESR1

BCL2 binding antagonists

NFE2L2-dependent BCL2 expression

MITF-dependent BCL2 expression

A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors.

Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells.

Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2.

Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis.

Parkin mono-ubiquitinates Bcl-2 and regulates autophagy.

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia.

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons.

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2.

BAG-1 modulates the chaperone activity of Hsp70/Hsc70.

The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression.

Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture.

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal.

Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein.

bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells.

bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy.

Proapoptotic BAX and BAK control multiple initiator caspases.

Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1.

T-2 toxin induces apoptosis, and selenium partly blocks, T-2 toxin induced apoptosis in chondrocytes through modulation of the Bax/Bcl-2 ratio.

The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.

MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.

Bcl-G, a novel pro-apoptotic member of the Bcl-2 family.

A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity.

Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak.

PUMA induces the rapid apoptosis of colorectal cancer cells.

BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.

The immunolocalization of Bcl-2 in human term placenta.

Medium from irradiated cells induces dose-dependent mitochondrial changes and BCL2 responses in unirradiated human keratinocytes.

Iron induces Bcl-2 expression in human dermal microvascular endothelial cells.

Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells.

Regulation of acidification and apoptosis by SHP-1 and Bcl-2.

A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis.

Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins.

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria.

Bcl-2 maintains B cell memory.

Deep research report on BCL2

Channel formation by antiapoptotic protein Bcl-2.

Conversion of Bcl-2 to a Bax-like death effector by caspases.

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.

Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue.

Role of Bcl-2 expression for productive herpes simplex virus 2 replication.

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair.

Expression of Bcl-2 protein in murine neural cells in culture.

BCL2 conditional proapoptotic and channel capacities: focused OpenScientist report