PMID:1346131(https://pubmed.ncbi.nlm.nih.gov/1346131/) reconstitutes mammalian Hsp60/Hsp10 substrate folding with MgATP; PMID:25918392(https://pubmed.ncbi.nlm.nih.gov/25918392/), DOI 10.1073/pnas.1411718112, solves the human type I chaperonin complex. These establish the distinction from the cytosolic type II TRiC/CCT system, independently of an AI review or ARBA.
Horse F6Z587 has 541 residues versus 573 for human P10809, with an internal deletion of human 171–202. The N-terminal mitochondrial precursor and annotated ATP-binding positions are conserved. Broad ATP binding and mitochondrial targeting remain reasonable inferences, but full ATP-dependent folding competence is uncertain for this model. The existing horse ARBA GO:0005832 TRiC-complex annotation is wrong at family/complex level regardless of whether this deletion preserves Hsp60 activity.
PMID:17823127(https://pubmed.ncbi.nlm.nih.gov/17823127/) shows that cytosolic Hsp60 can promote death or survival in different apoptotic systems, with different caspase-3 interactions. Do not remove opposing apoptotic-direction annotations solely because they share a reference. Immune responses to extracellular preparations require their own preparation/contamination and receptor-dependence controls; those rows remain UNDECIDED rather than being accepted as a universal Hsp60 cytokine activity or rejected from localization alone.
A completed human Falcon report has been inspected. The selected horse record is unreviewed; the initial literature search did not identify a targeted horse HSPD1 mechanistic experiment warranting a separate horse Edison report.
The completed Falcon report identifies PMID:32317635(https://pubmed.ncbi.nlm.nih.gov/32317635/), DOI:10.1038/s41467-020-15698-8, which establishes active single- and double-ring human Hsp60–Hsp10 assemblies. It also identifies PMID:31444388(https://pubmed.ncbi.nlm.nih.gov/31444388/), DOI:10.1038/s41598-019-48762-5, on impaired client refolding by disease variants. These primary identities were independently verified. ATP turnover and productive folding are distinct readouts, strengthening the caution about the selected horse deletion. The earlier manual synthesis is retained as separately labeled primary-source analysis.